PC Access attempted to write to the current agent's Home Directory and could not. (You should only see this particular error message if you are running a network version of PC Access.)
The error message gives the complete path to the agent's network Home Directory. This consists of the Shared Path (from the Defaults Setup window) followed by the Home Directory. The message also gives the error that PC Access received from Windows. If that error is "permission denied," then you most probably do not have write permission to this directory. If the error is "no such file or directory," then the directory probably does not exist. In either case you will need to report this problem to your network administrator. If you and your network administrator are unable to determine the cause of this error, follow the instructions for an Internal Error.
Also see File Error for general advice on reducing these kinds of errors.